New application of silk covered diamond in medical field

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Abstract Silk and diamond, two seemingly incompatible things, have been skillfully combined by scientists to successfully develop new applications for bioimaging and drug delivery. Scientists from Australia and the United States have recently been in the American Optical Society (OSA) journal Biomedic...
Silk and synthetic diamonds, two seemingly incompatible things, have been skillfully combined by scientists to successfully develop new applications for bioimaging and drug delivery.

Scientists in Australia and the United States recently published a joint study in the American Optical Society (OSA) journal Biomedical Optics Express, which said that the silk-coated synthetic diamond particles made of special materials have been developed, referred to as silk-coated diamond technology. When the wire-coated diamond is illuminated by specific light, the researchers can use this property to implant the wire-coated diamond particles into the cells, carefully observe the cells and break the molecular circuit mechanism that controls the behavior of the cells, or study the cells. The reaction of the drug. Researchers predict that the technology will help doctors directly deliver antibiotics to the affected areas in the future, greatly improving the treatment effect.

Nano-diamond has been developed in drug delivery technology, but the development of medical technology with silk wire coated with silk is the first case. The first author of the study, Professor Asma Khalid of the University of Melbourne, introduced the new diamond particle technology for bioimaging, biosensing and drug delivery.

Wire-covered diamond implanted on a dyed silicon substrate. Nanodiamond particles are implanted on the substrate, and then covered with a layer of special material

Diamond is a simple substance of carbon crystals, and other atoms can be embedded in the crystal structure, so that the defective diamond can absorb and emit light of a specific wavelength, that is, fluorescence; this is a characteristic that other pure diamonds do not have. Because fluorescent diamonds are bright at room temperature, stable in performance, and harmless to human tissue, scientists have used them in bioimaging and sensing technologies in the medical field. Previous studies have found that the burr edge of diamond particles may cause it to hang on the body of the tissue as it moves through the body tissue, so scientists extract a lipid from fat and wax and wrap it in diamond particles. Outside, make it smoother. The latest research explores a better method of silk coating, which encapsulates nanodiamonds with a transparent, soft, biodegradable and biodegradable filament. This design does not cause any side effects on human tissue.

In the experimental observation, the researchers found that the silk thread in the implanted tissue remained transparent, which not only did not affect the optical properties of the nano-diamond, but also enhanced the brightness of the diamond by 2 to 4 times. After two weeks of observation, the scientists concluded that the silk-coated diamond did not cause any side effects and tissue inflammation in human tissue.

The silk-coated diamond material implanted in the living tissue for two weeks did not cause any inflammation.

The research team envisions that the technology will be used in the treatment of infected organisms in the future: directly transplanting the drug-coated silk-coated diamond film to the affected area, minimizing the direct use of the drug and the unknown side effects caused to the patient. At the same time, the degradation rate of the silk thread can be designed to control the release of the drug and the timing of treatment.

The University of Melbourne in Australia, the University of Sydney and the University of Tufts participated in the study. (Compiled from 'Silk coat for diamonds makes sleek new imaging and drug delivery tool')

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